Potential biomarker identification in Parkinson´s Disease.


Parkinson’s disease is a neurodegenerative disorder framed in Movement Disorders. Parkinson’s Disease is the most common form of Parkinsonism; term that designates clinical diseases with similar characterization. Its core symptoms are bradykinesia, tremor, rigidity, and postural instability, there are other possible symptoms associated with the disease, such as, anxiety, depression, autonomic symptoms (daytime excessive sleepiness, erectile dysfunction and constipation), cognitive symptoms (cognitive impairment, attentional disfunction, visuospatial dysfunction, and memory impairment), comprising a heterogeneous disease.

The origin of the disease remains unknown, it is postulated as a result of many variables such as genetic susceptibility, environmental factors, and other factors. Nowadays, beside the advanced approaches and therapies for Parkinson’s management, (Deep Brain Stimulation), there is not a cure available. Therefore, detecting and developing sensitive biomarkers to detect the disease even in preclinical stages remains crucial.

A biomarker is a substance that indicates a biological state, either by its presence, absence, or change in physiological levels.

The main goal of the study is to develop, in a general way, a quick, non invasive and reliable method, for Parkinson Disease diagnosis from preclinical and initial clinical stages, by biochemical biomarker and biomaterial science with an improved surface enhanced Raman Spectrometry analysis. 

Inclusion criteria:

  • Age: 18 years old or more.
  • Parkinson’s Disease diagnosis by a clinical.
  • Capability for understanding  and  signing the informed consent

Patients can participate for research protocols freely or leave the volunteering if:

  • There is a disease or medical condition that puts health or functionality at risk
  • Personal wish to leave the volunteering.

As part of the studio there can be required some of these conditions: 

  • Taking specific medication.
  • Realizing diagnostic or classification tests.
  • Follow up testing
  • Realizing blood or neuroimaging tests.

Patients who wish participate and appear to be good candidates for research protocols may ask to any PRISMA specialist for additional information and beginning the eligibility process.

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